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Apoptosis Induction by OTA and TNF-α in Cultured Primary Rat Hepatocytes and Prevention by Silibinin

In cultures of primary rat hepatocytes, apoptosis occurred after application of 20 ng/mL tumor necrosis factor alpha (TNF-α). However, this was only in the presence of 200 ng/mL of the transcriptional inhibitor actinomycin D (ActD). This toxic effect was completely prevented in the presence of 25 µg...

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Detalles Bibliográficos
Autores principales: Essid, Ebtisam, Dernawi, Yousef, Petzinger, Ernst
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509701/
https://www.ncbi.nlm.nih.gov/pubmed/23202309
http://dx.doi.org/10.3390/toxins4111139