A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease

A genome-scale RNAi screen was performed in a mammalian cell-based assay to identify modifiers of mutant huntingtin toxicity. Ontology analysis of suppressor data identified processes previously implicated in Huntington's disease, including proteolysis, glutamate excitotoxicity, and mitochondri...

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Detalles Bibliográficos
Autores principales: Miller, John P., Yates, Bridget E., Al-Ramahi, Ismael, Berman, Ari E., Sanhueza, Mario, Kim, Eugene, de Haro, Maria, DeGiacomo, Francesco, Torcassi, Cameron, Holcomb, Jennifer, Gafni, Juliette, Mooney, Sean D., Botas, Juan, Ellerby, Lisa M., Hughes, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510027/
https://www.ncbi.nlm.nih.gov/pubmed/23209424
http://dx.doi.org/10.1371/journal.pgen.1003042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510027/
https://www.ncbi.nlm.nih.gov/pubmed/23209424
http://dx.doi.org/10.1371/journal.pgen.1003042

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