Transcription Elongation and Tissue-Specific Somatic CAG Instability

The expansion of CAG/CTG repeats is responsible for many diseases, including Huntington's disease (HD) and myotonic dystrophy 1. CAG/CTG expansions are unstable in selective somatic tissues, which accelerates disease progression. The mechanisms underlying repeat instability are complex, and it...

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Detalles Bibliográficos
Autores principales: Goula, Agathi-Vasiliki, Stys, Agnieszka, Chan, Jackson P. K., Trottier, Yvon, Festenstein, Richard, Merienne, Karine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510035/
https://www.ncbi.nlm.nih.gov/pubmed/23209427
http://dx.doi.org/10.1371/journal.pgen.1003051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510035/
https://www.ncbi.nlm.nih.gov/pubmed/23209427
http://dx.doi.org/10.1371/journal.pgen.1003051

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