Discovering Thiamine Transporters as Targets of Chloroquine Using a Novel Functional Genomics Strategy

Chloroquine (CQ) and other quinoline-containing antimalarials are important drugs with many therapeutic benefits as well as adverse effects. However, the molecular targets underlying most such effects are largely unknown. By taking a novel functional genomics strategy, which employs a unique combina...

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Detalles Bibliográficos
Autores principales: Huang, Zhiwei, Srinivasan, Sankaranarayanan, Zhang, Jianhuai, Chen, Kaifu, Li, Yongxiang, Li, Wei, Quiocho, Florante A., Pan, Xuewen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510038/
https://www.ncbi.nlm.nih.gov/pubmed/23209439
http://dx.doi.org/10.1371/journal.pgen.1003083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510038/
https://www.ncbi.nlm.nih.gov/pubmed/23209439
http://dx.doi.org/10.1371/journal.pgen.1003083

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