Spastic Paraplegia Mutation N256S in the Neuronal Microtubule Motor KIF5A Disrupts Axonal Transport in a Drosophila HSP Model

Hereditary spastic paraplegias (HSPs) comprise a group of genetically heterogeneous neurodegenerative disorders characterized by spastic weakness of the lower extremities. We have generated a Drosophila model for HSP type 10 (SPG10), caused by mutations in KIF5A. KIF5A encodes the heavy chain of kin...

Descripción completa

Detalles Bibliográficos
Autores principales: Füger, Petra, Sreekumar, Vrinda, Schüle, Rebecca, Kern, Jeannine V., Stanchev, Doychin T., Schneider, Carola D., Karle, Kathrin N., Daub, Katharina J., Siegert, Vera K., Flötenmeyer, Matthias, Schwarz, Heinz, Schöls, Ludger, Rasse, Tobias M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510046/
https://www.ncbi.nlm.nih.gov/pubmed/23209432
http://dx.doi.org/10.1371/journal.pgen.1003066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510046/
https://www.ncbi.nlm.nih.gov/pubmed/23209432
http://dx.doi.org/10.1371/journal.pgen.1003066

Ejemplares similares