Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression

Genomic instability drives tumorigenesis, but how it is initiated in sporadic neoplasias is unknown. In early preneoplasias, alterations at chromosome fragile sites arise due to DNA replication stress. A frequent, perhaps earliest, genetic alteration in preneoplasias is deletion within the fragile F...

Descripción completa

Detalles Bibliográficos
Autores principales: Saldivar, Joshua C., Miuma, Satoshi, Bene, Jessica, Hosseini, Seyed Ali, Shibata, Hidetaka, Sun, Jin, Wheeler, Linda J., Mathews, Christopher K., Huebner, Kay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510054/
https://www.ncbi.nlm.nih.gov/pubmed/23209436
http://dx.doi.org/10.1371/journal.pgen.1003077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510054/
https://www.ncbi.nlm.nih.gov/pubmed/23209436
http://dx.doi.org/10.1371/journal.pgen.1003077

Ejemplares similares