TLR2 and TLR4 Mediate Differential Responses to Limb Ischemia through MyD88-Dependent and Independent Pathways

INTRODUCTION: The danger signal HMGB1 is released from ischemic myocytes, and mediates angiogenesis in the setting of hindlimb ischemia. HMGB1 is a ligand for innate immune receptors TLR2 and TLR4. While both TLR2 and TLR4 signal through myeloid differentiation factor 88 (MyD88), TLR4 also uniquely...

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Detalles Bibliográficos
Autores principales: Sachdev, Ulka, Cui, Xiangdong, McEnaney, Ryan, Wang, Tian, Benabou, Kelly, Tzeng, Edith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510193/
https://www.ncbi.nlm.nih.gov/pubmed/23209800
http://dx.doi.org/10.1371/journal.pone.0050654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510193/
https://www.ncbi.nlm.nih.gov/pubmed/23209800
http://dx.doi.org/10.1371/journal.pone.0050654

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