Placebo Cohorts in Phase-3 MS Treatment Trials – Predictors for On-Trial Disease Activity 1990-2010 Based on a Meta-Analysis and Individual Case Data

BACKGROUND: Annualized relapse rates (ARR) in the placebo cohorts of phase-3 randomized controlled trials (RCT) of new treatments for relapsing remitting multiple sclerosis (RRMS) have decreased substantially during the last two decades. The causes of these changes are not clear. We consider a bette...

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Detalles Bibliográficos
Autores principales: Stellmann, Jan-Patrick, Neuhaus, Anneke, Herich, Lena, Schippling, Sven, Roeckel, Matthias, Daumer, Martin, Martin, Roland, Heesen, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510222/
https://www.ncbi.nlm.nih.gov/pubmed/23209717
http://dx.doi.org/10.1371/journal.pone.0050347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510222/
https://www.ncbi.nlm.nih.gov/pubmed/23209717
http://dx.doi.org/10.1371/journal.pone.0050347

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