Molecular Anatomy and Number of Antigen Specific CD8 T Cells Required to Cause Type 1 Diabetes

We quantified CD8 T cells needed to cause type 1 diabetes and studied the anatomy of the CD8 T cell/beta (β) cell interaction at the immunologic synapse. We used a transgenic model, in situ tetramer staining to distinguish antigen specific CD8 T cells from total T cells infiltrating islets and a var...

Descripción completa

Detalles Bibliográficos
Autores principales: Oldstone, Michael B. A., Edelmann, Kurt H., McGavern, Dorian B., Cruite, Justin T., Welch, Megan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510245/
https://www.ncbi.nlm.nih.gov/pubmed/23209415
http://dx.doi.org/10.1371/journal.ppat.1003044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510245/
https://www.ncbi.nlm.nih.gov/pubmed/23209415
http://dx.doi.org/10.1371/journal.ppat.1003044

Ejemplares similares