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Molecular Anatomy and Number of Antigen Specific CD8 T Cells Required to Cause Type 1 Diabetes

We quantified CD8 T cells needed to cause type 1 diabetes and studied the anatomy of the CD8 T cell/beta (β) cell interaction at the immunologic synapse. We used a transgenic model, in situ tetramer staining to distinguish antigen specific CD8 T cells from total T cells infiltrating islets and a var...

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Detalles Bibliográficos
Autores principales:	Oldstone, Michael B. A., Edelmann, Kurt H., McGavern, Dorian B., Cruite, Justin T., Welch, Megan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510245/ https://www.ncbi.nlm.nih.gov/pubmed/23209415 http://dx.doi.org/10.1371/journal.ppat.1003044

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