Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors

The modulation of 11β-HSD1 activity with selective inhibitors has beneficial effects on various metabolic disorders including insulin resistance, dyslipidemia and obesity. Here we report the discovery of a series of novel adamantyl carboxamide and acetamide derivatives as selective inhibitors of hum...

Descripción completa

Detalles Bibliográficos
Autores principales: Su, Xiangdong, Halem, Heather A., Thomas, Mark P., Moutrille, Cecile, Culler, Michael D., Vicker, Nigel, Potter, Barry V.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510433/
https://www.ncbi.nlm.nih.gov/pubmed/23040895
http://dx.doi.org/10.1016/j.bmc.2012.08.056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510433/
https://www.ncbi.nlm.nih.gov/pubmed/23040895
http://dx.doi.org/10.1016/j.bmc.2012.08.056

Ejemplares similares