Protein kinase A-mediated phosphorylation of RhoA on serine 188 triggers the rapid induction of a neuroendocrine-like phenotype in prostate cancer epithelial cells

Whilst androgen ablation therapy is used to treat locally advanced or metastatic forms of prostate cancer, side-effects can include the emergence of an androgen-independent neuroendocrine cell population which is associated with poor prognosis. Here we have examined how cyclic AMP elevation regulate...

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Detalles Bibliográficos
Autores principales: Jones, Sarah E., Palmer, Timothy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510439/
https://www.ncbi.nlm.nih.gov/pubmed/22504159
http://dx.doi.org/10.1016/j.cellsig.2012.03.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510439/
https://www.ncbi.nlm.nih.gov/pubmed/22504159
http://dx.doi.org/10.1016/j.cellsig.2012.03.018

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