Kinetic and thermodynamic characterization of the reaction pathway of box H/ACA RNA-guided pseudouridine formation

The box H/ACA RNA-guided pseudouridine synthase is a complicated ribonucleoprotein enzyme that recruits substrate via both the guide RNA and the catalytic subunit Cbf5. Structural studies have revealed multiple conformations of the enzyme, but a quantitative description of the reaction pathway is st...

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Detalles Bibliográficos
Autores principales: Yang, Xinxing, Duan, Jingqi, Li, Shuang, Wang, Peng, Ma, Shoucai, Ye, Keqiong, Zhao, Xin Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510513/
https://www.ncbi.nlm.nih.gov/pubmed/23012266
http://dx.doi.org/10.1093/nar/gks882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510513/
https://www.ncbi.nlm.nih.gov/pubmed/23012266
http://dx.doi.org/10.1093/nar/gks882

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