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Kinetic and thermodynamic characterization of the reaction pathway of box H/ACA RNA-guided pseudouridine formation
The box H/ACA RNA-guided pseudouridine synthase is a complicated ribonucleoprotein enzyme that recruits substrate via both the guide RNA and the catalytic subunit Cbf5. Structural studies have revealed multiple conformations of the enzyme, but a quantitative description of the reaction pathway is st...
Autores principales: | Yang, Xinxing, Duan, Jingqi, Li, Shuang, Wang, Peng, Ma, Shoucai, Ye, Keqiong, Zhao, Xin Sheng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510513/ https://www.ncbi.nlm.nih.gov/pubmed/23012266 http://dx.doi.org/10.1093/nar/gks882 |
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