Cargando…
α-Cleavage of cellular prion protein
The cellular prion protein (PrP(C)) is subjected to various processing under physiological and pathological conditions, of which the α-cleavage within the central hydrophobic domain not only disrupts a region critical for both PrP toxicity and PrP(C) to PrP(Sc) conversion but also produces the N1 fr...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510859/ https://www.ncbi.nlm.nih.gov/pubmed/23052041 http://dx.doi.org/10.4161/pri.22511 |