Shadoo/PrP (Sprn(0/0)/Prnp(0/0)) double knockout mice: More than zeroes

Shadoo (Sho) is a brain glycoprotein with similarities to the unstructured region of PrP(C). Frameshift alleles of the Sho gene, Sprn, are reported in variant Creutzfeldt-Jakob disease (vCJD) patients while Sprn mRNA knockdown in PrP-null (Prnp(0/0)) embryos produces lethality, advancing Sho as the...

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Detalles Bibliográficos
Autores principales: Daude, Nathalie, Westaway, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510864/
https://www.ncbi.nlm.nih.gov/pubmed/22929230
http://dx.doi.org/10.4161/pri.21867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510864/
https://www.ncbi.nlm.nih.gov/pubmed/22929230
http://dx.doi.org/10.4161/pri.21867

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