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Shadoo/PrP (Sprn(0/0)/Prnp(0/0)) double knockout mice: More than zeroes
Shadoo (Sho) is a brain glycoprotein with similarities to the unstructured region of PrP(C). Frameshift alleles of the Sho gene, Sprn, are reported in variant Creutzfeldt-Jakob disease (vCJD) patients while Sprn mRNA knockdown in PrP-null (Prnp(0/0)) embryos produces lethality, advancing Sho as the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510864/ https://www.ncbi.nlm.nih.gov/pubmed/22929230 http://dx.doi.org/10.4161/pri.21867 |