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An investigation of the auto-induction of and gender-related variability in the pharmacokinetics of dihydroartemisinin in the rat
BACKGROUND: Artemisinin (QHS) and its derivatives dihydroartemisinin (DHA), artemether and artesunate have become the first-line anti-malarials in areas of multidrug resistance. Declining plasma concentrations during the repeated dosing have been reported for QHS, artemether and less convincingly fo...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511063/ https://www.ncbi.nlm.nih.gov/pubmed/23171067 http://dx.doi.org/10.1186/1475-2875-11-379 |