Complement is dispensable for neurodegeneration in Niemann-Pick disease type C

BACKGROUND: The immune system has been implicated in neurodegeneration during development and disease. In various studies, the absence of complement (that is, C1q deficiency) impeded the elimination of apoptotic neurons, allowing survival. In the genetic lysosomal storage disease Niemann-Pick C (NPC...

Descripción completa

Detalles Bibliográficos
Autores principales: Lopez, Manuel E, Klein, Andres D, Scott, Matthew P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511250/
https://www.ncbi.nlm.nih.gov/pubmed/22985423
http://dx.doi.org/10.1186/1742-2094-9-216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511250/
https://www.ncbi.nlm.nih.gov/pubmed/22985423
http://dx.doi.org/10.1186/1742-2094-9-216

Ejemplares similares