Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice

BACKGROUND: The neuronal microtubule-associated protein tau becomes hyperphosphorylated and forms aggregates in tauopathies but the processes leading to this pathological hallmark are not understood. Because tauopathies are accompanied by neuroinflammation and the complement cascade forms a key inna...

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Detalles Bibliográficos
Autores principales: Britschgi, Markus, Takeda-Uchimura, Yoshiko, Rockenstein, Edward, Johns, Hudson, Masliah, Eliezer, Wyss-Coray, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511294/
https://www.ncbi.nlm.nih.gov/pubmed/22989354
http://dx.doi.org/10.1186/1742-2094-9-220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511294/
https://www.ncbi.nlm.nih.gov/pubmed/22989354
http://dx.doi.org/10.1186/1742-2094-9-220

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