Evaluation of Peripheral Blood Mononuclear Cell Processing and Analysis for Survival Motor Neuron Protein

OBJECTIVES: Survival Motor Neuron (SMN) protein levels may become key pharmacodynamic (PD) markers in spinal muscular atrophy (SMA) clinical trials. SMN protein in peripheral blood mononuclear cells (PBMCs) can be quantified for trials using an enzyme-linked immunosorbent assay (ELISA). We developed...

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Detalles Bibliográficos
Autores principales: Kobayashi, Dione T., Decker, Douglas, Zaworski, Phillip, Klott, Karen, McGonigal, Julie, Ghazal, Nabil, Sly, Laurel, Chung, Brett, Vanderlugt, James, Chen, Karen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511312/
https://www.ncbi.nlm.nih.gov/pubmed/23226377
http://dx.doi.org/10.1371/journal.pone.0050763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511312/
https://www.ncbi.nlm.nih.gov/pubmed/23226377
http://dx.doi.org/10.1371/journal.pone.0050763

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