The LEGSKO Mouse: A Mouse Model of Age-Related Nuclear Cataract Based on Genetic Suppression of Lens Glutathione Synthesis

Age-related nuclear cataracts are associated with progressive post-synthetic modifications of crystallins from various physical chemical and metabolic insults, of which oxidative stress is a major factor. The latter is normally suppressed by high concentrations of glutathione (GSH), which however ar...

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Detalles Bibliográficos
Autores principales: Fan, Xingjun, Liu, Xiaoqin, Hao, Shuyu, Wang, Benlian, Robinson, Michael L., Monnier, Vincent M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511334/
https://www.ncbi.nlm.nih.gov/pubmed/23226398
http://dx.doi.org/10.1371/journal.pone.0050832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511334/
https://www.ncbi.nlm.nih.gov/pubmed/23226398
http://dx.doi.org/10.1371/journal.pone.0050832

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