TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms

A cytokine/stress signaling kinase Tak1 (Map3k7) deficiency is known to impair hematopoietic progenitor cells. However, the role of TAK1 signaling in the stem cell function of the hematopoietic system is not yet well defined. Here we characterized hematopoietic stem cells (HSCs) harboring deletion o...

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Detalles Bibliográficos
Autores principales: Takaesu, Giichi, Inagaki, Maiko, Takubo, Keiyo, Mishina, Yuji, Hess, Paul R., Dean, Gregg A., Yoshimura, Akihiko, Matsumoto, Kunihiro, Suda, Toshio, Ninomiya-Tsuji, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511369/
https://www.ncbi.nlm.nih.gov/pubmed/23226465
http://dx.doi.org/10.1371/journal.pone.0051073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511369/
https://www.ncbi.nlm.nih.gov/pubmed/23226465
http://dx.doi.org/10.1371/journal.pone.0051073

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