Discovery of a Novel, Monocationic, Small-Molecule Inhibitor of Scrapie Prion Accumulation in Cultured Sheep Microglia and Rov Cells

Prion diseases, including sheep scrapie, are neurodegenerative diseases with the fundamental pathogenesis involving conversion of normal cellular prion protein (PrP(C)) to disease-associated prion protein (PrP(Sc)). Chemical inhibition of prion accumulation is widely investigated, often using rodent...

Descripción completa

Detalles Bibliográficos
Autores principales: Stanton, James B., Schneider, David A., Dinkel, Kelcey D., Balmer, Bethany F., Baszler, Timothy V., Mathison, Bruce A., Boykin, David W., Kumar, Arvind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511409/
https://www.ncbi.nlm.nih.gov/pubmed/23226483
http://dx.doi.org/10.1371/journal.pone.0051173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511409/
https://www.ncbi.nlm.nih.gov/pubmed/23226483
http://dx.doi.org/10.1371/journal.pone.0051173

Ejemplares similares