Discovery of a hapE Mutation That Causes Azole Resistance in Aspergillus fumigatus through Whole Genome Sequencing and Sexual Crossing

Azole compounds are the primary therapy for patients with diseases caused by Aspergillus fumigatus. However, prolonged treatment may cause resistance to develop, which is associated with treatment failure. The azole target cyp51A is a hotspot for mutations that confer phenotypic resistance, but in a...

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Detalles Bibliográficos
Autores principales: Camps, Simone M. T., Dutilh, Bas E., Arendrup, Maiken C., Rijs, Antonius J. M. M., Snelders, Eveline, Huynen, Martijn A., Verweij, Paul E., Melchers, Willem J. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511431/
https://www.ncbi.nlm.nih.gov/pubmed/23226235
http://dx.doi.org/10.1371/journal.pone.0050034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511431/
https://www.ncbi.nlm.nih.gov/pubmed/23226235
http://dx.doi.org/10.1371/journal.pone.0050034

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