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Characterization of LEDGF/p75 Genetic Variants and Association with HIV-1 Disease Progression
BACKGROUND: As Lens epithelium-derived growth factor (LEDGF/p75) is an important co-factor involved in HIV-1 integration, the LEDGF/p75-IN interaction is a promising target for the new class of allosteric HIV integrase inhibitors (LEDGINs). Few data are available on the genetic variability of LEDGF/...
Autores principales: | Messiaen, Peter, De Spiegelaere, Ward, Alcami, Jose, Vervisch, Karen, Van Acker, Petra, Verhasselt, Bruno, Meuwissen, Pieter, Calonge, Esther, Gonzalez, Nuria, Gutierrez-Rodero, Felix, Rodriguez-Martín, Carmen, Sermijn, Erica, Poppe, Bruce, Vogelaers, Dirk, Verhofstede, Chris, Vandekerckhove, Linos |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511443/ https://www.ncbi.nlm.nih.gov/pubmed/23226247 http://dx.doi.org/10.1371/journal.pone.0050204 |
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