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Immunotherapy of Tumors with α(2)-Macroglobulin-Antigen Complexes Pre-Formed In Vivo
The cell surface receptor CD91/LRP-1 binds to immunogenic heat shock proteins (HSP) and α(2)M ligands to elicit T cell immune responses. In order to generate specific immune responses, the peptides chaperoned by HSPs or α(2)M are cross-presented on MHC molecules to T cells. While the immunogenic HSP...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511516/ https://www.ncbi.nlm.nih.gov/pubmed/23226267 http://dx.doi.org/10.1371/journal.pone.0050365 |