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Immunotherapy of Tumors with α(2)-Macroglobulin-Antigen Complexes Pre-Formed In Vivo

The cell surface receptor CD91/LRP-1 binds to immunogenic heat shock proteins (HSP) and α(2)M ligands to elicit T cell immune responses. In order to generate specific immune responses, the peptides chaperoned by HSPs or α(2)M are cross-presented on MHC molecules to T cells. While the immunogenic HSP...

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Detalles Bibliográficos
Autores principales:	Pawaria, Sudesh, Kropp, Laura E., Binder, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511516/ https://www.ncbi.nlm.nih.gov/pubmed/23226267 http://dx.doi.org/10.1371/journal.pone.0050365

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