Withaferin A Induces Proteasome Inhibition, Endoplasmic Reticulum Stress, the Heat Shock Response and Acquisition of Thermotolerance

In the present study, withaferin A (WA), a steroidal lactone with anti-inflammatory and anti-tumor properties, inhibited proteasome activity and induced endoplasmic reticulum (ER) and cytoplasmic HSP accumulation in Xenopus laevis A6 kidney epithelial cells. Proteasomal inhibition by WA was indicate...

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Detalles Bibliográficos
Autores principales: Khan, Saad, Rammeloo, Ashley W., Heikkila, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511540/
https://www.ncbi.nlm.nih.gov/pubmed/23226310
http://dx.doi.org/10.1371/journal.pone.0050547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511540/
https://www.ncbi.nlm.nih.gov/pubmed/23226310
http://dx.doi.org/10.1371/journal.pone.0050547

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