Attenuation of Cell Mechanosensitivity in Colon Cancer Cells during In Vitro Metastasis

Human colon carcinoma (HCT-8) cells show a stable transition from low to high metastatic state when cultured on appropriately soft substrates (21 kPa). Initially epithelial (E) in nature, the HCT-8 cells become rounded (R) after seven days of culture on soft substrate. R cells show a number of metas...

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Detalles Bibliográficos
Autores principales: Tang, Xin, Wen, Qi, Kuhlenschmidt, Theresa B., Kuhlenschmidt, Mark S., Janmey, Paul A., Saif, Taher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511581/
https://www.ncbi.nlm.nih.gov/pubmed/23226284
http://dx.doi.org/10.1371/journal.pone.0050443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511581/
https://www.ncbi.nlm.nih.gov/pubmed/23226284
http://dx.doi.org/10.1371/journal.pone.0050443

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