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Attenuation of Cell Mechanosensitivity in Colon Cancer Cells during In Vitro Metastasis
Human colon carcinoma (HCT-8) cells show a stable transition from low to high metastatic state when cultured on appropriately soft substrates (21 kPa). Initially epithelial (E) in nature, the HCT-8 cells become rounded (R) after seven days of culture on soft substrate. R cells show a number of metas...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511581/ https://www.ncbi.nlm.nih.gov/pubmed/23226284 http://dx.doi.org/10.1371/journal.pone.0050443 |