Histone Methylase MLL1 plays critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivo

Mixed lineage leukemias (MLL) are human histone H3 lysine-4 specific methyl transferases that play critical roles in gene expression, epigenetics, and cancer. Herein, we demonstrated that antisense-mediated knockdown of MLL1 induced cell cycle arrest and apoptosis in cultured cells. Intriguingly, ap...

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Detalles Bibliográficos
Autores principales: Ansari, Khairul I., Kasiri, Sahba, Mandal, Subhrangsu S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511651/
https://www.ncbi.nlm.nih.gov/pubmed/22926525
http://dx.doi.org/10.1038/onc.2012.352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511651/
https://www.ncbi.nlm.nih.gov/pubmed/22926525
http://dx.doi.org/10.1038/onc.2012.352

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