Structural basis for engagement by complement factor H of C3b on a self surface

Complement factor H (FH) attenuates C3b molecules tethered via their thioester domains to self-surfaces and thereby protects host tissues. FH is a cofactor for initial C3b proteolysis that ultimately yields a surface-attached fragment (C3d), corresponding to the thioester domain. We used NMR and X-r...

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Detalles Bibliográficos
Autores principales: Morgan, Hugh P., Schmidt, Christoph Q., Guariento, Mara, Blaum, Bärbel S., Gillespie, Dominic, Herbert, Andrew P., Kavanagh, David, Mertens, Haydyn D. T., Svergun, Dmitri I., Johansson, Conny M., Uhrín, Dušan, Barlow, Paul N., Hannan, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512577/
https://www.ncbi.nlm.nih.gov/pubmed/21317894
http://dx.doi.org/10.1038/nsmb.2018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512577/
https://www.ncbi.nlm.nih.gov/pubmed/21317894
http://dx.doi.org/10.1038/nsmb.2018

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