260 Association Between Genetic Polymorphisms of ABCC2 Transporter and the Susceptibility to Maculopapular Eruption Induced by Antituberculosis Drugs

BACKGROUND: ATP-binding cassette (ABC) transporter proteins play an important role in drug disposition. Polymorphisms of ABC transporter genes (ABCC2 and ABCB1) may be risk markers for maculopapular eruption (MPE) induced by unusual accumulation of antituberculosis drugs (ATD) itself or metabolites. METHODS: We compared genotype distributions of single nucleotide polymorphisms and haplotypes in ABCC2 and ABCB1 genes between 62 ATD-induced MPE cases and 159 ATD-tolerant controls using multivariate logistic regression analysis. RESULTS: Among the 7 selected SNPs of ABCC2, -1549G>A in promoter and IVS3-49C>T in intron were associated with ATD-induced MPE (P = 0.032 and P = 0.029, respectively). ABCC2 haplotype1 [G-C-C-G] was significantly associated with ATD-induced MPE (P = 0.032, OR = 0.35, 95% CI, 0.29-0.95). However, there was no significant association between other genetic polymorphisms in ABCB1 and ATD-induced MPE. CONCLUSIONS: These results suggest that genetic variations of ABCC2 are a potential risk factor for ATD-induced MPE.