A genetic approach to the prediction of drug side effects: bleomycin induces concordant phenotypes in mice of the collaborative cross

The antineoplastic drug bleomycin leads to the side effect of pulmonary fibrosis in both humans and mice. We challenged genetically diverse inbred lines of mice from the Collaborative Cross with bleomycin to determine the heritability of this phenotype. Sibling pairs of mice from 40 lines were treat...

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Detalles Bibliográficos
Autores principales: Gelinas, Richard, Chesler, Elissa J, Vasconcelos, Daphne, Miller, Darla R, Yuan, Yue, Wang, Kai, Galas, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513218/
https://www.ncbi.nlm.nih.gov/pubmed/23226052
http://dx.doi.org/10.2147/PGPM.S22475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513218/
https://www.ncbi.nlm.nih.gov/pubmed/23226052
http://dx.doi.org/10.2147/PGPM.S22475

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