Human Monoclonal Antibodies against Glucagon Receptor Improve Glucose Homeostasis by Suppression of Hepatic Glucose Output in Diet-Induced Obese Mice

AIM: Glucagon is an essential regulator of hepatic glucose production (HGP), which provides an alternative therapeutic target for managing type 2 diabetes with glucagon antagonists. We studied the effect of a novel human monoclonal antibody against glucagon receptor (GCGR), NPB112, on glucose homeos...

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Detalles Bibliográficos
Autores principales: Kim, Wook-Dong, Lee, Yong-ho, Kim, Min-Hee, Jung, Sun-Young, Son, Woo-Chan, Yoon, Seon-Joo, Lee, Byung-Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513295/
https://www.ncbi.nlm.nih.gov/pubmed/23226550
http://dx.doi.org/10.1371/journal.pone.0050954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513295/
https://www.ncbi.nlm.nih.gov/pubmed/23226550
http://dx.doi.org/10.1371/journal.pone.0050954

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