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Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier
Radiation therapy (RT) after breast conservation therapy has recently been linked with significant reduction in risk of ipsilateral breast cancer among BRCA1 mutation carriers. However, the exact mechanism by which RT reduces incidence of BRCA1-associated cancer remains unclear. Here we studied fres...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514114/ https://www.ncbi.nlm.nih.gov/pubmed/23210696 http://dx.doi.org/10.1186/2162-3619-1-31 |
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author | Chiang, Huai-Chin Nair, Sreejith J Yeh, I-Tien Santillan, Alfredo A Hu, Yanfen Elledge, Richard Li, Rong |
author_facet | Chiang, Huai-Chin Nair, Sreejith J Yeh, I-Tien Santillan, Alfredo A Hu, Yanfen Elledge, Richard Li, Rong |
author_sort | Chiang, Huai-Chin |
collection | PubMed |
description | Radiation therapy (RT) after breast conservation therapy has recently been linked with significant reduction in risk of ipsilateral breast cancer among BRCA1 mutation carriers. However, the exact mechanism by which RT reduces incidence of BRCA1-associated cancer remains unclear. Here we studied fresh breast tissue from a BRCA1 mutation carrier who was initially treated with a lumpectomy and RT for a unilateral cancer and two years later chose a prophylactic bilateral mastectomy while remaining cancer-free. Flow cytometry analysis demonstrated a strikingly lower luminal cell population in the irradiated breast as compared to the non-irradiated breast, which was confirmed by immunohistochemistry. Furthermore, the irradiated breast tissue exhibited very low progenitor cell activity in vitro. Given the emerging evidence that BRCA1 tumors originate from luminal progenitor cells, our observations suggest that preferential and long-lasting elimination of luminal ductal epithelium may partly underlie the mechanism of RT-associated reduction in recurrence of BRCA1-associated cancer. |
format | Online Article Text |
id | pubmed-3514114 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35141142012-12-05 Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier Chiang, Huai-Chin Nair, Sreejith J Yeh, I-Tien Santillan, Alfredo A Hu, Yanfen Elledge, Richard Li, Rong Exp Hematol Oncol Case Report Radiation therapy (RT) after breast conservation therapy has recently been linked with significant reduction in risk of ipsilateral breast cancer among BRCA1 mutation carriers. However, the exact mechanism by which RT reduces incidence of BRCA1-associated cancer remains unclear. Here we studied fresh breast tissue from a BRCA1 mutation carrier who was initially treated with a lumpectomy and RT for a unilateral cancer and two years later chose a prophylactic bilateral mastectomy while remaining cancer-free. Flow cytometry analysis demonstrated a strikingly lower luminal cell population in the irradiated breast as compared to the non-irradiated breast, which was confirmed by immunohistochemistry. Furthermore, the irradiated breast tissue exhibited very low progenitor cell activity in vitro. Given the emerging evidence that BRCA1 tumors originate from luminal progenitor cells, our observations suggest that preferential and long-lasting elimination of luminal ductal epithelium may partly underlie the mechanism of RT-associated reduction in recurrence of BRCA1-associated cancer. BioMed Central 2012-10-08 /pmc/articles/PMC3514114/ /pubmed/23210696 http://dx.doi.org/10.1186/2162-3619-1-31 Text en Copyright ©2012 Chiang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Chiang, Huai-Chin Nair, Sreejith J Yeh, I-Tien Santillan, Alfredo A Hu, Yanfen Elledge, Richard Li, Rong Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier |
title | Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier |
title_full | Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier |
title_fullStr | Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier |
title_full_unstemmed | Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier |
title_short | Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier |
title_sort | association of radiotherapy with preferential depletion of luminal epithelial cells in a brca1 mutation carrier |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514114/ https://www.ncbi.nlm.nih.gov/pubmed/23210696 http://dx.doi.org/10.1186/2162-3619-1-31 |
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