Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system

BACKGROUND: Amyloid beta peptide (Aβ) is the main component of extraneuronal senile plaques typical of Alzheimer’s disease (AD) brains. Although Aβ is produced by normal neurons, it is shown to accumulate in large amounts within neuronal lysosomes in AD. We have recently shown that under normal cond...

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Detalles Bibliográficos
Autores principales: Zheng, Lin, Cedazo-Minguez, Angel, Hallbeck, Martin, Jerhammar, Fredrik, Marcusson, Jan, Terman, Alexei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514139/
https://www.ncbi.nlm.nih.gov/pubmed/23210724
http://dx.doi.org/10.1186/2047-9158-1-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514139/
https://www.ncbi.nlm.nih.gov/pubmed/23210724
http://dx.doi.org/10.1186/2047-9158-1-19

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