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Metabolic Alterations and Increased Liver mTOR Expression Precede the Development of Autoimmune Disease in a Murine Model of Lupus Erythematosus

Although metabolic syndrome (MS) and systemic lupus erythematosus (SLE) are often associated, a common link has not been identified. Using the BWF1 mouse, which develops MS and SLE, we sought a molecular connection to explain the prevalence of these two diseases in the same individuals. We determine...

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Detalles Bibliográficos
Autores principales: Vilà, Laia, Roglans, Núria, Baena, Miguel, Barroso, Emma, Alegret, Marta, Merlos, Manuel, Laguna, Juan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514194/
https://www.ncbi.nlm.nih.gov/pubmed/23226562
http://dx.doi.org/10.1371/journal.pone.0051118