Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

Blood-brain barrier disruption, microglial activation and neurodegeneration are hallmarks of multiple sclerosis. However, the initial triggers that activate innate immune responses and their role in axonal damage remain unknown. Here we show that the blood protein fibrinogen induces rapid microglial...

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Detalles Bibliográficos
Autores principales: Davalos, Dimitrios, Kyu Ryu, Jae, Merlini, Mario, Baeten, Kim M., Le Moan, Natacha, Petersen, Mark A., Deerinck, Thomas J., Smirnoff, Dimitri S., Bedard, Catherine, Hakozaki, Hiroyuki, Gonias Murray, Sara, Ling, Jennie B., Lassmann, Hans, Degen, Jay L., Ellisman, Mark H., Akassoglou, Katerina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514498/
https://www.ncbi.nlm.nih.gov/pubmed/23187627
http://dx.doi.org/10.1038/ncomms2230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514498/
https://www.ncbi.nlm.nih.gov/pubmed/23187627
http://dx.doi.org/10.1038/ncomms2230

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