Complex DNA repair pathways as possible therapeutic targets to overcome temozolomide resistance in glioblastoma

Many conventional chemotherapeutic drugs exert their cytotoxic function by inducing DNA damage in the tumor cell. Therefore, a cell-inherent DNA repair pathway, which reverses the DNA-damaging effect of the cytotoxic drugs, can mediate therapeutic resistance to chemotherapy. The monofunctional DNA-a...

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Detalles Bibliográficos
Autores principales: Yoshimoto, Koji, Mizoguchi, Masahiro, Hata, Nobuhiro, Murata, Hideki, Hatae, Ryusuke, Amano, Toshiyuki, Nakamizo, Akira, Sasaki, Tomio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514620/
https://www.ncbi.nlm.nih.gov/pubmed/23227453
http://dx.doi.org/10.3389/fonc.2012.00186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514620/
https://www.ncbi.nlm.nih.gov/pubmed/23227453
http://dx.doi.org/10.3389/fonc.2012.00186

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