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Noise–mean relationship in mutated promoters

Gene expression depends on the frequency of transcription events (burst frequency) and on the number of mRNA molecules made per event (burst size). Both processes are encoded in promoter sequence, yet their dependence on mutations is poorly understood. Theory suggests that burst size and frequency c...

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Detalles Bibliográficos
Autores principales: Hornung, Gil, Bar-Ziv, Raz, Rosin, Dalia, Tokuriki, Nobuhiko, Tawfik, Dan S., Oren, Moshe, Barkai, Naama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514670/
https://www.ncbi.nlm.nih.gov/pubmed/22820945
http://dx.doi.org/10.1101/gr.139378.112