Cargando…

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle–vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of membrane states upon Ca(2+)-injection at 250–500...

Descripción completa

Detalles Bibliográficos
Autores principales:	Diao, Jiajie, Grob, Patricia, Cipriano, Daniel J, Kyoung, Minjoung, Zhang, Yunxiang, Shah, Sachi, Nguyen, Amie, Padolina, Mark, Srivastava, Ankita, Vrljic, Marija, Shah, Ankita, Nogales, Eva, Chu, Steven, Brunger, Axel T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2012
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514886/ https://www.ncbi.nlm.nih.gov/pubmed/23240085 http://dx.doi.org/10.7554/eLife.00109

Ejemplares similares

Correction: Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion
por: Diao, Jiajie, et al.
Publicado: (2015)

Complexin inhibits spontaneous release and synchronizes Ca(2+)-triggered synaptic vesicle fusion by distinct mechanisms
por: Lai, Ying, et al.
Publicado: (2014)

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
por: Diao, Jiajie, et al.
Publicado: (2013)

Complexin-1 Enhances the On-Rate of Vesicle Docking via Simultaneous SNARE and Membrane Interactions
por: Diao, Jiajie, et al.
Publicado: (2013)

Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex
por: Choi, Ucheor B, et al.
Publicado: (2016)

Towards reconstitution of membrane fusion mediated by SNAREs and other synaptic proteins
por: Brunger, Axel T., et al.
Publicado: (2015)

Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals
por: Uervirojnangkoorn, Monarin, et al.
Publicado: (2015)

Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex
por: Baskaran, Sulochanadevi, et al.
Publicado: (2014)

Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex
por: Lyubimov, Artem Y, et al.
Publicado: (2016)

Munc18a Does Not Alter Fusion Rates Mediated by Neuronal SNAREs, Synaptotagmin, and Complexin
por: Zhang, Yunxiang, et al.
Publicado: (2015)

Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis
por: Ma, Lu, et al.
Publicado: (2015)

Structural snapshots of Xer recombination reveal activation by synaptic complex remodeling and DNA bending
por: Bebel, Aleksandra, et al.
Publicado: (2016)

Post-Translational Modifications and Lipid Binding Profile of Insect Cell-Expressed Full-Length Mammalian Synaptotagmin 1
por: Vrljic, Marija, et al.
Publicado: (2011)

Contacts-based prediction of binding affinity in protein–protein complexes
por: Vangone, Anna, et al.
Publicado: (2015)

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate
por: Schotten, Sebastiaan, et al.
Publicado: (2015)

Correction: Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate
por: Schotten, Sebastiaan, et al.
Publicado: (2015)

Molecular architecture of human polycomb repressive complex 2
por: Ciferri, Claudio, et al.
Publicado: (2012)

Codon-level information improves predictions of inter-residue contacts in proteins by correlated mutation analysis
por: Jacob, Etai, et al.
Publicado: (2015)

Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes
por: Lee, Sang Hak, et al.
Publicado: (2017)

Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1
por: van Dorp, Stijn, et al.
Publicado: (2021)

Correction: Super-resolution imaging of synaptic and Extra-synaptic AMPA receptors with different-sized fluorescent probes
por: Lee, Sang Hak, et al.
Publicado: (2017)

Symmetry breaking in reconstituted actin cortices
por: Abu Shah, Enas, et al.
Publicado: (2014)

A novel region in the Ca(V)2.1 α(1) subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone
por: Lübbert, Matthias, et al.
Publicado: (2017)

Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography
por: Keedy, Daniel A, et al.
Publicado: (2015)

Computational model of the full-length TSH receptor
por: Mezei, Mihaly, et al.
Publicado: (2022)

Deconstruction of the Ras switching cycle through saturation mutagenesis
por: Bandaru, Pradeep, et al.
Publicado: (2017)

Aerodynamic forces and flows of the full and partial clap-fling motions in insects
por: Cheng, Xin, et al.
Publicado: (2017)

The complete structure of the human TFIIH core complex
por: Greber, Basil J, et al.
Publicado: (2019)

Pi-Pi contacts are an overlooked protein feature relevant to phase separation
por: Vernon, Robert McCoy, et al.
Publicado: (2018)

Differential impact of BTK active site inhibitors on the conformational state of full-length BTK
por: Joseph, Raji E, et al.
Publicado: (2020)

Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor
por: Ivica, Josip, et al.
Publicado: (2022)

Stochastic, structural and functional factors influencing AMPA and NMDA synaptic response variability: a review
por: Maio, Vito Di, et al.
Publicado: (2017)

Crystal structure of the full Swi2/Snf2 remodeler Mot1 in the resting state
por: Butryn, Agata, et al.
Publicado: (2018)

Ribosome•RelA structures reveal the mechanism of stringent response activation
por: Loveland, Anna B, et al.
Publicado: (2016)

Incubator-independent cell-culture perfusion platform for continuous long-term microelectrode array electrophysiology and time-lapse imaging
por: Saalfrank, Dirk, et al.
Publicado: (2015)

Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction
por: Laxmikanthan, Gurunathan, et al.
Publicado: (2016)

Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts
por: Boyaci, Hande, et al.
Publicado: (2018)

Structure and flexibility of the yeast NuA4 histone acetyltransferase complex
por: Zukin, Stefan A, et al.
Publicado: (2022)

Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement
por: Patel, Avinash B, et al.
Publicado: (2019)

Single-molecule FRET-derived model of the synaptotagmin 1–SNARE fusion complex
por: Choi, Ucheor B., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_7ugeeaq2v80tf6drca4l0m46jl