The class I PI3K/Akt pathway is critical for cancer cell survival in dogs and offers an opportunity for therapeutic intervention

BACKGROUND: Using novel small-molecular inhibitors, we explored the feasibility of the class I PI3K/Akt/mTORC1 signaling pathway as a therapeutic target in canine oncology either by using pathway inhibitors alone, in combination or combined with conventional chemotherapeutic drugs in vitro. RESULTS:...

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Detalles Bibliográficos
Autores principales: Chen, Yu-Ting, Tan, Karen AL, Pang, Lisa Y, Argyle, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515332/
https://www.ncbi.nlm.nih.gov/pubmed/22647622
http://dx.doi.org/10.1186/1746-6148-8-73

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515332/
https://www.ncbi.nlm.nih.gov/pubmed/22647622
http://dx.doi.org/10.1186/1746-6148-8-73

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