Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative diseases, but it has been difficult to develop selective inhibitors against caspases. We report the discovery and characterization of a potent inhibitor of caspase-6 that acts by an uncompetitive binding mode that...

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Detalles Bibliográficos
Autores principales: Heise, Christopher E., Murray, Jeremy, Augustyn, Katherine E., Bravo, Brandon, Chugha, Preeti, Cohen, Frederick, Giannetti, Anthony M., Gibbons, Paul, Hannoush, Rami N., Hearn, Brian R., Jaishankar, Priyadarshini, Ly, Cuong Q., Shah, Kinjalkumar, Stanger, Karen, Steffek, Micah, Tang, Yinyan, Zhao, Xianrui, Lewcock, Joseph W., Renslo, Adam R., Flygare, John, Arkin, Michelle R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515450/
https://www.ncbi.nlm.nih.gov/pubmed/23227217
http://dx.doi.org/10.1371/journal.pone.0050864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515450/
https://www.ncbi.nlm.nih.gov/pubmed/23227217
http://dx.doi.org/10.1371/journal.pone.0050864

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