Synergistic Effects of Combined Wnt/KRAS Inhibition in Colorectal Cancer Cells

Activation of Wnt signalling due to inability to degrade β-catenin is found in >85% of colorectal cancers. Approximately half of colon cancers express a constitutively active KRAS protein. A significant fraction of patients show both abnormalities. We previously reported that simultaneous down-re...

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Detalles Bibliográficos
Autores principales: Mologni, Luca, Brussolo, Stefania, Ceccon, Monica, Gambacorti-Passerini, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515485/
https://www.ncbi.nlm.nih.gov/pubmed/23227266
http://dx.doi.org/10.1371/journal.pone.0051449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515485/
https://www.ncbi.nlm.nih.gov/pubmed/23227266
http://dx.doi.org/10.1371/journal.pone.0051449

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