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Synergistic Effects of Combined Wnt/KRAS Inhibition in Colorectal Cancer Cells
Activation of Wnt signalling due to inability to degrade β-catenin is found in >85% of colorectal cancers. Approximately half of colon cancers express a constitutively active KRAS protein. A significant fraction of patients show both abnormalities. We previously reported that simultaneous down-re...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515485/ https://www.ncbi.nlm.nih.gov/pubmed/23227266 http://dx.doi.org/10.1371/journal.pone.0051449 |