Proton-Shuttling Lichen Compound Usnic Acid Affects Mitochondrial and Lysosomal Function in Cancer Cells

The lichen compound usnic acid (UA) is a lipophilic weak acid that acts as a proton shuttle and causes loss of mitochondrial inner membrane potential. In the current study we show that UA treatment induced the formation of autophagosomes in human cancer cells, but had minimal effects on normal human...

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Detalles Bibliográficos
Autores principales: Bessadottir, Margret, Egilsson, Mar, Einarsdottir, Eydis, Magnusdottir, Iris H., Ogmundsdottir, Margret H., Omarsdottir, Sesselja, Ogmundsdottir, Helga M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515546/
https://www.ncbi.nlm.nih.gov/pubmed/23227259
http://dx.doi.org/10.1371/journal.pone.0051296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515546/
https://www.ncbi.nlm.nih.gov/pubmed/23227259
http://dx.doi.org/10.1371/journal.pone.0051296

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