Immuno-Isolation of Pancreatic Islet Allografts Using Pegylated Nanotherapy Leads to Long-Term Normoglycemia in Full MHC Mismatch Recipient Mice

Two major hurdles need to be surmounted for cell therapy for diabetes: (i) allo-immune rejection of grafted pancreatic islets, or stem/precursor cell-derived insulin-secreting cells; and (ii) continuing auto-immunity against the diabetogenic endogenous target antigen. Nanotherapeutics offer a novel...

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Detalles Bibliográficos
Autores principales: Dong, Huansheng, Fahmy, Tarek M., Metcalfe, Su M., Morton, Steve L., Dong, Xiao, Inverardi, Luca, Adams, David B., Gao, Wenda, Wang, Hongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515593/
https://www.ncbi.nlm.nih.gov/pubmed/23227162
http://dx.doi.org/10.1371/journal.pone.0050265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515593/
https://www.ncbi.nlm.nih.gov/pubmed/23227162
http://dx.doi.org/10.1371/journal.pone.0050265

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