AGR2 is a SMAD4-suppressible gene that modulates MUC1 levels and promotes the initiation and progression of pancreatic intraepithelial neoplasia

The mechanisms controlling expression of the putative oncogene AGR2 in pancreatic ductal adenocarcinoma (PDAC) are not well understood. We now show that AGR2 is a TGF-β-responsive gene in human pancreatic cancer cells, whose down-regulation is SMAD4-dependent. We also provide evidence supporting a r...

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Detalles Bibliográficos
Autores principales: Norris, A.M., Gore, A., Balboni, A., Young, A., Longnecker, D.S., Korc, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515713/
https://www.ncbi.nlm.nih.gov/pubmed/22945649
http://dx.doi.org/10.1038/onc.2012.394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515713/
https://www.ncbi.nlm.nih.gov/pubmed/22945649
http://dx.doi.org/10.1038/onc.2012.394

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